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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
23.33
Human Site:
S668
Identified Species:
42.78
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
S668
S
E
D
D
V
L
S
S
S
S
C
G
S
N
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
S662
S
E
D
D
V
L
S
S
S
S
C
G
S
N
S
Dog
Lupus familis
XP_546130
745
81496
S666
S
E
D
D
V
L
S
S
S
S
C
G
S
N
S
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
S658
S
E
D
D
V
L
S
S
S
S
C
G
S
N
S
Rat
Rattus norvegicus
Q5RJQ4
350
39301
A277
M
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
S407
S
C
G
S
N
S
D
S
G
T
C
H
S
P
S
Chicken
Gallus gallus
NP_001004767
756
82614
S680
S
E
D
D
M
I
S
S
S
S
C
G
S
S
S
Frog
Xenopus laevis
NP_001091195
710
78684
F630
I
F
H
G
A
E
V
F
S
D
S
E
E
E
L
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
F306
S
F
G
G
G
M
D
F
D
S
D
K
A
Y
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
D704
N
D
Y
S
D
D
D
D
E
E
E
E
R
S
H
Honey Bee
Apis mellifera
XP_395386
868
98678
S746
P
E
E
Y
D
H
C
S
L
S
I
N
S
E
S
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
S534
H
H
E
T
H
C
E
S
S
C
G
S
S
C
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
H430
I
V
N
M
V
P
S
H
V
P
Q
I
L
I
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
6.6
N.A.
33.3
80
6.6
13.3
N.A.
0
33.3
26.6
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
26.6
N.A.
40
100
6.6
26.6
N.A.
20
40
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
8
0
0
0
0
16
0
0
% A
% Cys:
0
8
0
0
0
8
8
0
0
8
47
0
0
8
0
% C
% Asp:
0
16
39
47
16
8
24
8
8
8
16
0
0
0
0
% D
% Glu:
0
47
16
0
0
8
8
0
8
8
8
16
8
16
0
% E
% Phe:
0
16
8
0
0
0
0
16
0
0
0
0
0
0
0
% F
% Gly:
0
0
16
16
8
0
0
0
8
0
8
39
0
0
0
% G
% His:
8
8
8
0
8
8
0
8
0
0
0
8
0
0
8
% H
% Ile:
16
0
0
0
0
8
0
0
0
0
8
8
0
8
0
% I
% Lys:
0
0
0
0
0
8
8
0
0
0
0
8
0
0
0
% K
% Leu:
0
0
0
0
0
31
0
0
8
0
0
0
8
0
16
% L
% Met:
8
0
0
8
8
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
8
0
8
0
0
0
0
0
0
8
0
31
8
% N
% Pro:
8
0
0
0
0
8
0
0
0
8
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
8
% R
% Ser:
54
0
0
16
8
8
47
62
54
54
8
8
62
16
62
% S
% Thr:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
8
0
0
39
0
8
0
8
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
8
8
0
0
0
0
8
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _